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na112/2; Gna142/2 at both low and high light intensities. Consistent with previous studies, MKOs exhibited deficits at high light intensities. Surprisingly, all mice mutant for Gq/11 genes were indistinguishable from WT animals at both low and high light intensities. We also recorded wheel-running activity in 46 month old WT, MKO, Gna15 KO, Gnaq; Gna11 DKO, and Gna11; Gna14 DKO mice to measure the